Aspire A514-52k Which RAM and SSD should I use

Definitely Yes , Both the ram frequency and choosing of ssd matters.

if we are compairing 3200 mHz ram vs 2133 mHz ram , for sure there will be difference in the performance.

As i can see above , Your laptop can hold upto , 2133 mHz ram , even if you put a 3200 mHz ram on your laptop,the system will lower your ram frequency by default to 2133 mHz, also more frequency ram are more costly.

so there is no sense of buying a more frequency ram , if your laptop only supports upto 2133 mHz

When coming to ssd , nvme have more read and write speed since it is using the new 'PClE' technology for transferring data , at the same time normal ssd drives use 'SATA' technology for transferring data.

Although its up to you , if you want best performance you can go for nvme ssd , which is more costly.

But that dosent means normal 2.5 inch ssd drives are bad.

But still the performance of normal ssd drives are below nvme ssd drives when comapiring.

Remember there are nvme ssd drives which uses sata connection technology ( b key , b+m key )

If you want to buy a nvme ssd over normal ssd , always buy PClE nvme ssd drives ( m key )

eg : samsung evo plus

*Also make sure what type of slot you have on your laptop for upgrading your storage through ssd