I installed 2018-11 Cumulative Update for Windows 10 Version 1803 for x64-based Systems (KB4467702) in November my Acer Aspire XC-730 desktop. Since then both keyboard and mouse stop responding after about 5 minutes without any manual input. Whilst using the PC then there is no problem. The only way to progress is to hard shut down the PC and restart.
I have seen others with a similar issue though not necessarily from this Windows 10 update. The solutions recommended seemed complex and beyond my confidence. I had hoped that Microsoft would have been informed of this problem and would be sending out an update to fix, but to date none seen.