See the images below. Both images are captured when the issue occurs. The first is from a camera because the second is from a Windows screen grab. As you can see what I see is a distorted screen. I have two more displays connected that do not exhibit this issue when this monitor does (they are dell monitors)
All monitors are using DisplayPort with nVidia 2-way SLI (happened before I used SLI as well). For some reason the image captured is fine but the display is distorted. I have tried shifting all the settings in the OSD, resetting in the OSD and turning GSync on/off. The only thing that resolves the issue is a hard reboot.
Image captured with external camera.

Image captured with screen grab (SnagIt)

Thanks in advance.